MyBioSource.com's RANK antibody (biotin) is a Rat monoclonal antibody. This antibody has been shown to work in applications such as: Flow Cytometry.
Description
Rat monoclonal RANK antibody (biotin)
The R12-31 monoclonal antibody reacts with mouse RANK, a recently cloned member of the TNFR superfamily with no significant homology to other members of this family. RANK ligand binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. The cytoplasmic domain of RANK interacts with TRAF2, TRAF5 and TRAF6. Overexpression of RANK activates NF-kappaB and c-Jun-terminal kinase pathways. Recent studies have shown that RANK interaction with TRAF6 activates NF-kappaB, whereas JNK activation is mediated through binding of RANK to TRAF2